Pharmacokinetics of transdermal buprenorphine patch in the elderly
نویسندگان
چکیده
منابع مشابه
Management of chronic pain in the elderly: focus on transdermal buprenorphine
Chronic pain in the elderly is a significant problem. Pharmacokinetic and metabolic changes associated with increased age makes the elderly vulnerable to side effects and overdosing associated with analgesic agents. Therefore the management of chronic cancer pain and chronic nonmalignant pain in this growing population is an ongoing challenge. New routes of administration have opened up new tre...
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BACKGROUND Donepezil is an acetylcholinesterase inhibitor indicated for Alzheimer's disease. The aim of this randomized, single-blind, placebo-controlled, single-dose, dose-escalation study was to investigate the safety, tolerability, and pharmacokinetics of the donepezil patch in healthy male subjects. METHODS Each healthy male subject received a single transdermal donepezil patch (72 hours ...
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BACKGROUND Cholinesterase inhibitors have all been available in oral formulations, but a rivastigmine transdermal patch has now been developed and is approved in many countries worldwide for the treatment of mild-to-moderate Alzheimer's disease (AD) (including the USA, Latin America, Europe and Asia). OBJECTIVES To review the available pharmacokinetic data that supported the rationale behind ...
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BACKGROUND AND OBJECTIVES Rotigotine is a dopamine receptor agonist with activity across the D1 through to D5 receptors as well as select serotonergic and adrenergic sites; continuous transdermal delivery of rotigotine with replacement of the patch once daily maintains stable plasma concentrations over 24 h. Rotigotine is indicated for the treatment of early and advanced-stage Parkinson's disea...
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By virtue of their efficacy, opioid analgesics have long been used for the treatment of both acute and chronic pain. Concerns regarding their safety and tolerability have frequently prevented this class of drugs achieving their full therapeutic potential, and their reported association with drug abuse and dependence has led to a reduced acceptance by many patients. Indeed, there is a variety of...
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ژورنال
عنوان ژورنال: European Journal of Clinical Pharmacology
سال: 2012
ISSN: 0031-6970,1432-1041
DOI: 10.1007/s00228-012-1320-8